The pain medications are not equal, nor reduce fever. In particular, the two commonly used drugs, acetaminophen (paracetamol) and ibuprofen, help with pain and is commonly used to treat fever. However, belonging to two different classes of drugs and have completely different mechanisms of action and side effects. What is safer, the acetaminophen or ibuprofen?
The facts: Ibuprofen vs acetaminophen
Both are analgesics or painkillers. They also reduce the fever, which makes antipyretics. Scientists do not know exactly how acetaminophen works to relieve pain, but is believed to increase the pain threshold. Its ability to reduce fever is due to its direct action on the hypothalamus in the brain. Unlike ibuprofen, or acetaminophen acetaminophen has no anti-inflammatory properties.
Risk Factors of analgesics
Ibuprofen belongs to a class of medications called NSAIDs or non-steroidal, also described as COX 1 and 2 (cyclooxygenase). Has a stronger action than paracetamol, but many people are limited because it can promote bleeding. Ibuprofen stops pain by inhibiting the release of prostaglandins (hormones) that cause inflammation and pain in the body. Endorphins, natural stress and pain, then allowed to move freely, helping to relieve pain. Concomitant use of carbamazepine, phenytoin and barbiturates also been reported as a risk factor for hepatotoxicity or liver damage Risk factors to consider when taking ibuprofen include a history of bleeding, use of drugs to thin the blood, heart disease, heart failure and ulcer. Kidney damage can occur from prolonged use of high doses and patients with renal impairment may be at risk, with much lower doses. The caution in the elderly is particularly important. Those at risk of heart attack or stroke should also be careful when using ibuprofen. The short-term use is the best approach to minimize the risk factors associated with the drug.
History of acetaminophen and ibuprofen
Acetaminophen became available in 1955 as an elixir for children, introduced by McNeil Laboratories, later acquired by Johnson & Johnson in 1959 and has been widely sold since. Charles Gerhardt Tylenol discovered in 1852. The first description is in the chemical literature since 1878. The drug received little attention until 1951, when researchers presented results showing that was as effective as aspirin in reducing pain and fever described in a symposium in New York sponsored by the Institute for the Study of analgesics and sedatives. Ibuprofen was discovered by Dr. Stewart Adams, John Nicholson and Colin Burrows, the two colleagues Dr. Adams, in an attempt to find a safer drug than aspirin. Work began in the 1950s and ibuprofen was first synthesized in 1961, with further development in 1964. It was introduced in the UK as a treatment for rheumatoid arthritis at a lower than currently recommended doses. In 1974, a patient was delivered in the United States at a dose of 1200-3200 mg / day. Ibuprofen, acetaminophen unlike, is available at a higher dose with a prescription.
The counter medications are not necessarily safe. If you’re looking relieve pain or treat fever, you must first speak with your doctor whether acetaminophen or ibuprofen are suitable for you. Medication should always be taken at the recommended dose, more is not better. Recognize the difference in action and side effects of both can help you make better decisions about your health care needs.
No medication will cause drowsiness or dependence, and people without health problems, can be used in conjunction with others to provide maximum benefit. Again, talk to your doctor about dosage, usage and personal benefits of the use of acetaminophen compared to ibuprofen.